Selected Publications and Patents

 
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Download Paper Liu, D., Wu, X., Summers, M.D., Lee, A., Ryan, K.J., and Braunagel, S.C. 2010. Truncated isoforms of Kap60 Facilitate Trafficking of Heh2 to the nuclear envelope. Traffic 11: 1506-1518.
Download Paper Braunagel, S.C., Cox, V. and Summers, M.D. 2009. Baculovirus suggest a common but multi-faceted pathway for sorting proteins to the inner nuclear membrane. J. Virol. 83:1280-1288. This article was highlighted In the Journal of Virology Spotlight.
Download Paper Braunagel, S.C. and Summers, M.D. 2007. Molecular biology of the baculovirus occlusion-derived virus envelope, Curro Drug Targ, 8:1084-1095.
Download Paper Braunagel, S.C., Williamson, S.W. Ding, Q., Wu, W. and Summers, M.D. 2007. Early sorting of inner nuclear membrane proteins is conserved. Proc. Natl. Acad. Sci. USA 104:9307-9312.
Download Paper Burks, J.K., Summers, M.D. and Braunagel, S.C. 2007. BV/ODV-E26: a palmitoylated, multifunctional protein of Autographa californica nucleopolyhedrovirus. Virology, 361 :194-203.
Download Paper Summers, M.D, 2006. Milestones leading to the genetic engineering of baculoviruses as expression vector systems and viral pesticides. IN: Advances in Virus Research (ed. B. Bonning) 68:3-73, Academic Press, Elsevier, NY.
Suraj Saksena, Max D Summers, Jared K Burks, Arthur E. Johnson and Sharon C. Braunagel(2006) Importin alpha-16: a translocon-associated protein potentially involved in sorting integral membrane proteins to the nuclear envelope. Nat. Struct. Mol. Biol. 13:#6, 500-508.

Saksena, S, Shao, Y, Braunagel, S, Summers, MD, and Johnson, AE 2004. Cotranslational integration and initial sorting at the ER translocon of proteins destined for the inner nuclear membrane. Proc. Natl. Acad. Sci. USA. 101:12537-12542.

Braunagel SC, Williamson ST, Saksena S, Zhong Z, Russell WK, Russell DH, Summers MD. 2004. Trafficking of ODV-E66 is mediated via a sorting motif and other viral proteins: Facilitated trafficking to the inner nuclear membrane. Proc Natl Acad Sci U S A. 101: 8372-8377.

Braunagel, S.C., Russell, W.K., Rosas-Acosta, G., Russell, D.H., and Summers, M.D. 2003. Determination of the Protein Composition of the Occlusion-Derived Virus of Autographa californica nucleopolyhedrovirus. Proc. Nat. Acad. Sci., USA. 100: 9797-9802.

Braunagel, S.C., Guidry, P.A., Rosas-Acosta, G., Engelking, L., and Summers, M.D. 2001. Identification of BV/ODV-C42: A structural protein of Autographa californica nucelopolyhedrovirus (orf101) is present in infected cell complexes which include ODV-EC27 and p78/83. J.Virol. 75 (24): 12331-12338.

Rosas-Acosta, G., Braunagel, S.C., and Summers, M.D. 2001. Effects of deletion and over-expression of the AcMNPV FP25K gene on the synthesis of two occlusion-derived virus envelope proteins and their transport into virus-induced intranuclear membranes of two ODV envelope proteins. J. Virol. 75 (22): 10829-10842.

Webb, B.A., Beckage, N.E., Hayakawa, Y., Krell, P.J., Lanzrein, B., Stoltz, D.B., Strand, M.R., and Summers, M.D. 2000. Family Polydnaviridae: In Virus Taxonomy Classification and Homenclature of Viruses: Seventh report of the International Committee of Taxonomy of Viruses (M.H.V. van Regenmortel, C.M. Fauquet, D.H.L. Bishop, E.B. Carsteins, M.K. Estesm S.M. Lemon, J. maniloff, M.A. Mayo, D.J. McGeoch, C.R. Pringle, R.B. Wickner, editors) Academic Press, San Diego. Pp. 253-260.

Braunagel, S.C., Burks, J.K., Rosas-Acosta, G., Harrison, R., Ma, H., and Summers, M.D. 1999. Mutations within Autographa californica nucleopolyhedrovirus FP25K gene inhibits nuclear transport of ODV-E66. J. Virol. 73:8559-857

Belyavskyi, M., Braunagel, S.C. and Summers, M.D. 1998. Autographa californica nucleopolyhedrovirus codes a multi-functional cyclin. Proc. Natl. Acad. Sci. USA 95(19): 11205-11210.

Braunagel, S.C., Parr, R., Belyavsyki, M. and Summers, M.D. 1998. Autographa californica nuclear polyhedrosis virus infection results in Sf9 cell cycle arrest at G2/M phase. Virology 244:195-211.

Beniya, H., Braunagel, S.C. and Summers, M.D. 1997. Autographa californica nuclear polyhedrosis virus: subcellular localization and protein trafficking of BV/ODV-E26 to plasma membrane, intranuclear membranes and viral envelopes. Virology 240:64-75.

Hong, T., Summers, M.D. and Braunagel, S.C. 1997. N-terminal sequences from Autographa californica nuclear polyhedrosis virus envelope proteins ODV-E66 and ODV-E25 are sufficient to direct reporter proteins to the nuclear envelope, intranuclear microvesicles and the envelope of occlusion derived virus. Proc. Nat. Acad. Sci., USA 94(8):4050-4055.

Harrison, R.L., Jarvis, D.L. and Summers, M.D. 1996. The role of the AcMNPV 25K gene in baculovirus polh and p10 gene expression. Virology, 226:34-46.

Braunagel, S.C, He, H., Ramamurthy, P. and Summers, M.D. 1996. Transcription, translation, and cellular localization of three Autographa californica nuclear polyhedrosis virus structural proteins: ODV-E18, ODV-E35 and ODV-EC27. Virology, 222:100-114.

Braunagel, S.C., Elton, D.M., Ma, H. and Summers, M.D. 1996. Identification and analysis of an Autographa californica nuclear polyhedrosis virus structural protein of the occlusion-derived virus envelope: ODV-E56. Virology. 217:97-110.

Harrison, R.L. and Summers, M.D. 1995. Mutations in the Autographa californica multinucleocapsid nuclear polyhedrosis virus 25 kDa protein gene result in reduced virion occlusion, altered intranuclear envelopment and enhanced virus production. J. Gen. Virol.76:1451-1459.

Harrison, R.L. and Summers, M.D. 1995. Biosynthesis and localization of the Autographa californica nuclear polyhedrosis virus 25K gene product. Virology 208:279-288.

Summers, M.D. and Dib-Hajj, S.D. 1995. Polydnavirus-facilitated endoparasite protection against host immune defenses. Proc. Nat. Acad. Sci. U.S.A. 92 (1):29-36.

Hong, T., Braunagel, S.C., Summers, M.D. 1994. Transcription, translation, and cellular localization of PDV-E66: A structural protein of the PDV envelope of Autographa californica nuclear polyhedrosis virus. Virology 204: 210-222.

Braunagel, S. C. and Summers, M. D. 1994. Autographa californica nuclear polyhedrosis virus, PDV and ECV viral envelopes and nucleo-capsids: Structural proteins; antigens; lipid and fatty acid profiles. Virology 202: 315-328

Jarvis, D. L., Summers, M. D., Garcia, Jr., A., and Bohlmeyer, D. A. 1993. Influence of different signal peptides and prosequences on expression and secretion of human tissue plasminogen activator in the baculovirus system. J. Biol. Chem. 268(22):16754-16762.

Dib-Hajj, S.D., Webb, B.A., and Summers, M.D. 1993. Structure and evolutionary implications of a “cysteine-rich” Campoletis sonorensis polydnavirus gene family. Proc. Nat. Acad. Sci. U.S.A 90:3765-3769.

Braunagel, S.C., Daniel, K.D., Reilly, L.M., Guarino, L.A., Hong, T., and Summers, M.D. 1992. Sequence, Genomic Organization of the EcoRI-A Fragment of Autographa californica Nuclear Polyhedrosis Virus, and Identification of a Viral-Encoded Protein Resembling the Outer Capsid Protein VP8 of Rotavirus. Virology 191:1003-1008.

Webb, B.A., and Summers, M.D. 1992. Stimulation of polydnavirus replication by 20-hydroxyecdysone. Experientia 48:1018-1022.

Kovacs, Gerald R., Choi, Jene, Guarino, Linda A., and Summers, M.D. 1992. Functional Dissection of the Autographa californica Nuclear Polyhedrosis Virus Immediate Early-1 Transcriptional Regulatory Protein. J. Virol. 66:7429-74

Jarvis, D.L. and Summers, M.D. 1992. "Baculovirus expression vectors" IN: Recombinant DNA Vaccines: Rationale and Strategies (R.E. Isaacson, ed.) Marcel Kekker, Inc. pp. 265-291.

Seppänen, H., Huhtala, M.-L., Vaheri, A., Summers, M.D., and Oker-Blom, C. 1991. Diagnostic potential of baculovirus-expressed rubella virus envelope proteins. J. Clinical Microbiology 29:1877-1882.

Kovacs, G.R., Guarino, L.A., Graham, B.L., and Summers, M.D. 1991. Identification of spliced baculovirus RNAs expressed late in infection. Virology 185:633-643.

Carson, D.D., Summers, M.D., and Guarino, L.A. 1991. Transient expression of the AcMNPV immediate early gene, IE-N, is regulated by three viral elements. J. Virol. 65:945-951.

Beames, B., Braunagel, S., Summers, M.D., and Lanford, R.E. 1991. Polyhedrin Initiator Codon Altered to AUU Yields Unexpected Fusion Protein from a Baculovirus Vector. Biotechniques: 11:378-383.

Kovacs, G.R., Guarino, L.A., and Summers, M.D. 1991. Novel regulatory properties of the IE1 and IE0 transactivators encoded by the baculovirus Autographa californica multicapsid nuclear polyhedrosis virus. J. Virol. 65:5281-5288.

Fleming, J.G.W., and Summers, M.D. 1991. Polydnaviral DNA is integrated in parasitoid host wasp DNA. Proc. Natl. Aca. Sci. USA 88:9770-9774.

Carson, D.D., Summers, M.D., and Guarino, L.A. 1991. Molecular analysis of a baculovirus regulatory gene. Virology 182:279-286.


Fleming, J.G.W. and Summers, M.D. 1990. The integration of the genome of a segmented DNA virus in the host insect's genome. IN: Molecular Insect Science (Hagedorn, H.H., Hildebrand, J. and Law, J., eds.), Plenum Press, New York. pp. 99-105.

Summers, M.D. 1990. Baculovirus Directed Foreign Gene Expression. IN: Proceedings of the American Chemical Society, pp. 99-105.

Webb, N.R., and Summers, M.D. 1990. Expression of proteins using recombinant baculoviruses. Technique 2:173-188.

Oker-Blom, C., Jarvis, D.L., and Summers, M.D. 1990. Translocation and cleavage of rubella virus envelope glycoproteins: Identification and role of the E2 signal sequence. J. Gen. Virol. 71:3047-3053.

Webb, B.A., and Summers, M.D. 1990. Venom and viral expression products of the endoparasitic wasp, Campoletis sonorensis, share epitopes and related sequences. Proc. Natl. Acad. Sci. USA 87:4961-4965.

Jarvis, D.L., Fleming, J.G.W., Kovacs, G.R., Summers, M.D., and Guarino, L.A. 1990. Use of early baculovirus promoters for the continuous expression and efficient processing of foreign gene products in stably-transformed lepidopteran insect cells. Bio/Technology 8:950-955.

Jarvis, D.L., Oker-Blom, C., and Summers, M.D. 1990. The role of glycosylation in the transport of recombinant glycoproteins through the secretory pathway of lepidopteran insect cells. J. Cell. Biochem.42:181-191.

Beames, B., and Summers, M.D. 1990. Sequence comparison of cellular and viral copies of host cell DNA insertions found in Autographa californica nuclear polyhedrosis virus. Virology 174:354-363.

 

US Patents:

1.
US Patent No. 4,745,051: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted May 17, 1988)
2.  US Patent No. 4,879,236: Method for Producing a Recombinant Baculovirus Expression Vector. (Summers/Smith) (Granted November 7, 1989.)
3. US Patent No. 5,023,328: Lepidopteran AKH Signal Sequence. (Summers/Bradfield/Keeley) (Granted June 11, 1991.) 
4. US Patent No. 5,155,037: Insect Signal Sequences Useful to Improve the Efficiency of Processing and Secretion of Foreign Genes in Insect Systems. (Summers) (Granted October 13, 1992.)
5. US Patent No. 5,169,784: Baculovirus Dual Promoter Expression Vector. (Oker-Blom/Summers) (Granted December 8, 1992.) 
6.  US Patent No. 5, 278,050: Method to Improve the Efficiency of Processing and Secretion of Foreign Genes in Insect Systems. (Summers) (Granted June 11, 1994.) 
7. US Patent No. 08/792,832: Unique Sequence for Insertion of Foreign Proteins into the Autographa californica Nuclear Polyhedrosis Occlusion Derived Viral Envelope (Summers/Braunagel/Hong) (Granted October 12, 1998.)

 

Foreign Patents:

1. Spain Patent No. 532825: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted March 12, 1985.)
2. South Africa Patent No. 84/3914: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted September 25, 1985.) 
3. Canada Patent No. 1222213: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted May 26, 1987.) 
4. Argentina Patent No. 296755: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted June 30, 1987.) 
5. New Zealand Patent No. 208259: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted May 6, 1988.) 
6.  Australia Patent No. 581174: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted May 26, 1989.)
7.  India Patent No. 164388: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted September 15, 1989.) 
8. Philippines Patent No. 25395: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted June 3, 1991.) 
9.  Taiwan Patent No. 050740: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted December 26, 1991 -      Non- convention.) 
10. Korea Patent No. 51077: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted April 27, 1992.) 
11. Korea Patent No. 52829: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted July 6, 1992.) 
12. European Patent No. 0127839: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted July 15, 1992 - Designating Austria, Belgium, France, Great Britain, Italy, Luxembourg/ Liechtenstein, Netherlands, Sweden, Switzerland, West Germany.) 
13. Mexico Patent No. 164250: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted July 27, 1992.) 
14. Israel Patent No. 71906: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted November 19, 1992.) 
15. Canada Patent No. 2091886: Multiple Promoter Baculovirus Expression System and Defective Particle Production. (Oker-Blom/Summers)  
16. Sweden Patent No. 91918840.9: Multiple Promoter Baculovirus Expression System and Defective Particle Production. (Oker-Blom/Summers)  
17. Eire Patent No. 58011: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted June 16, 1993.) 
18. Venezuelan Counterpart Patent No. 49131: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Granted February 4, 1993.) 
19. European Patent No. 0 549 721: Multiple Promoter Baculovirus Expression System and Defective Particle Production. (Oker-Blom/Summers) Granted April 13, 1994. -Designating Austria, Belgium, Denmark, France, Germany, Greece, Holland, Italy, Luxembourg, Spain, Switzerland.) 
20. Brazil Patent Application: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Pending) 
21. Colombia Patent Application: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Pending) 
22. Denmark Patent Application: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Pending) 
23. Japan Patent Application: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Pending) 
24. Korea-2 Patent Application: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Pending) 
25. Norway Patent Application: Method for Producing a Recombinant Baculovirus Expression Vector. (Smith/Summers) (Pending) 

TOTAL TO DATE (Publication Categories) Over 375