of the Accessory Proteins Involved in Protein Trafficking (Dr.
Sharon Braunagel and Dr. Qi Ding)
Qi Ding's current model for
the inner nuclear membrane (INM) protein trafficking is diffusion-retention:
proteins diffuse freely through the endoplasmic reticulum (ER), outer
nuclear membrane (ONM) and INM, the interaction with nucleoplasmic components
is the only factor to keep proteins residing in INM. However, our
previous data show that at least in insect cells, INM protein trafficking
is a multi-step protein regulated process. Qi studies the trafficking
of two mammalian INM proteins Lamin B receptor and Nurim. Using
site-specific crosslinking approach she is trying to identify the accessory
protein(s) involved in the trafficking process.