Reading List

GENE 481 Genetics I Seminar (Classic Papers in Molecular Genetics)

Fall 2008


Week 2: September 4 (base composition of DNA) bio: Chargaff

Chargaff, E. (1950) Chemical specificity of nucleic acids and mechanism of their enzymatic degradation. Experimentia 6:201-209)


Week 3: September 11 (structure of DNA) bios: Watson, Crick, Franklin, Wilkins

Watson, J.D. and Crick, F.H.C. (1953) Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. Nature 171:737-738.

Wilkins, M.H.F., Stokes, A.R., and Wilson, H.R. (1953) Molecular structure of nucleic acids. Molecular structure of deoxypentose nucleic acids. Nature 171:738-740.

Franklin, R.E. and Gosling, R.G. (1953) Molecular structure of nucleic acids. Molecular configuration in sodium thymonucleate. Nature 171:740-741.

Watson, J.D. and Crick, F.H.C. (1953) Genetical implications of the structure of deoxyribonucleic acid. Nature 171:964-967.


Week 4: September 18 (semi-conservative nature of DNA replication) bio: Meselson

Meselson, M. and Stahl, F.W. (1958) The replication of DNA in Escherichia coli. Proc. Natl. Acad. Sci. USA 44:671-682.


Week 5: September 25 (mRNA) bio: Brenner

Brenner, S., Jacob, F., and Meselson, M. (1961) An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature 190:576-581.


Week 6: October 2 (genetic code) bio: Nirenberg

Leder, P. and Nirenberg, M. (1964) RNA codewords and protein synthesis, II. Nucleotide sequence of a valine RNA codeword. Proc. Natl Acad. Sci. USA 52:420-427.


Week 7: October 9 (sigma factor of E. coli RNA polymerase) bio: Burgess

Burgess, R.R., Travers, A.A., Dunn, J.J., and Bautz, E.K.F. (1969) Factor Stimulating Transcription by RNA Polymerase. Nature 221:43-46.


Week 8: October 16 (reverse transcriptase) bios: Baltimore, Temin

Baltimore, D. (1970) RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses. Nature 226:1209-1211.

Temin, H.M. and Mizutani, S. (1970) RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus. Nature 226:1211-1213.


Week 9: October 23 (recombinant plasmids)- bios: Cohen, Boyer

Cohen, S., Chang, A., Boyer, H., and Helling, R. (1973) Construction of biologically functional bacterial plasmids in vitro. Proc. Natl. Acad. Sci. USA 70:3240-3244.


Week 10: October 30 (mRNA introns) bio: Sharp

Berget, S.M., Moore, C., and Sharp, P.A. (1977) Spliced segments at the 5 terminus of adenovirus 2 late mRNA. Proc. Natl. Acad. Sci. USA 74:3171-3175.


Week 11: November 6 (snRNPs) bio: JA Steitz

Lerner, M.R. and Steitz, J.A. (1979) Antibodies to small nuclear RNAs complexed with protein are produced by patients with systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA 76:5495-5499.


Week 12: November 13 (self-splicing RNA) bio: Cech

Kruger, K., Grabowski, P.J., Zaug, A.J., Sands, J., Gottschling, D.E., and Cech, T.R. (1982) Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell 31:147-157.


Week 13: November 20 (micro RNAs) bio: Ruvkun

Reinhart, B.J., Slack, F.J., Basson, M., Pasquinelli, A.E., Bettinger, J.C., Rougvie, A.E., Horvitz, H.R., and Ruvkun, G. (2000) The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403:901-906.