Quiz 4, BICH 410 (MWF 3-3:50P), Monday December 6, 1999
Write your name on each page. Clearly circle your response to each question. No partial credit for multiple-choice questions.
1. (3 pts) What compound results from a transamination reaction using glutamate?
- A) pyruvate
- B) oxaloacetate
- C) glutamate
- D) alpha-ketoglutarate
- E) succinate
2. (3 pts) Which combination of cofactors is involved in the conversion of pyruvate to acetyl-CoA by the pyruvate dehydrogenase complex?
- A) NAD, biotin, and thiamine pyrophosphate
- B) thiamine pyrophosphate, lipoic acid, and NAD
- C) ATP, FAD, and lipoic acid
- D) biotin, FAD, and thiamine pyrophosphate
- E) biotin, NAD, and FAD
3. (3 pts) The two moles of CO2 produced in the first turn of the citric acid cycle have their origin in the:
- A) two carbon atoms of acetate in acetyl-CoA.
- B) two carboxyl groups derived from oxaloacetate.
- C) carboxyl group of acetate (from acetyl-CoA) and the keto group of oxaloacetate.
- D) carboxyl group of acetate (from acetyl-CoA) and a carboxyl group of oxaloacetate.
- E) methyl group of acetate (from acetyl-CoA) and the keto group of oxaloacetate.
4. (3 pts) In the citric acid cycle, a flavin coenzyme (FAD) is required for:
- A) condensation of acetyl-CoA and oxaloacetate
- B) oxidation of isocitrate
- C) oxidation of succinate
- D) oxidation of malate
- E) hydration of fumarate
5. (3 pts) Which of the following enzymes is NOT inhibited by increased levels of NADH?
- A) pyruvate dehydrogenase kinase
- B) citrate synthase
- C) isocitrate dehydrogenase
- D) alpha-ketoglutarate dehydrogenase
- E) pyruvate dehydrogenase
6. (2 pts) Which of the following is NOT an intermediate in the citric acid cycle?
- A) succinyl-CoA
- B) fumarate
- C) aspartate
- D) isocitrate
- E) malate
7. (3 pts) Starting with one mole of pyruvate, how many moles of NADH are produced by its complete metabolism via the pyruvate dehydrogenase complex and one full turn of the citric acid cycle?
- A) one
- B) two
- C) three
- D) four
- E) five