BICH 407, Eukaryotic Transcription, Spring 2000

Reading List: Assigned Papers and Primary Discussants

Week of 1/24-28: Eukaryotic promoters / Gary Kunkel
McKnight, S.L. and Kingsbury, R. Transcriptional control signals of a eukaryotic protein-coding gene. (1982) Science 217:316-324.

Week of 1/31-2/4: Basal transcription factors / Ryan Loyd
Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH. (1992) J. Biol. Chem. 267:2786-2793.

Week of 2/7-11: Assembly of preinitiation complex / Joshua Loyd
Buratowski, S., Hahn, S., Guarente, L., and Sharp, P.A. Five Intermediate Complexes in Transcription Initiation by RNA Polymerase II. (1989) Cell 56:549-561.

Week of 2/14-18: RNA polymerase II holoenzyme / Erin Pinkerton
Koleske, A.J. and Young, R.A. An RNA polymerase II holoenzyme responsive to activators. (1994) Nature 368:466-469.

Week of 2/21-25: Structure of transcription factors (TATA-binding protein) / John Dyer
Kim, Y., Geiger, J.H., Hahn, S., and Sigler, P.B. Crystal structure of a yeast TBP/TATA-box complex. (1993) Nature 365:512-520.

Week of 2/28-3/3: Enhancers / Albert McDaniel
Rossert, J.A., Chen, S.S., Eberspaecher, H., Smith, C.N., and de Crombrugghe, B. Identification of a minimal sequence of the mouse pro-a1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts. (1996) Proc. Natl. Acad. Sci. USA 93:1027-1031.

Week of 3/6-10: Transcription of chromatin / Gary Kunkel
Laybourn, P.J. and Kadonaga, J.T. Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase II (1991) Science 254:238-245.

Week of 3/20-24: Chromatin modifying activity / Huong Nguyen
Brownell, J.E., Zhou, J., Ranalli, T., Kobayashi, R., Edmonson, D.G., Roth, S.Y., and Allis, C.D. Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation (1996) Cell 84:843-851.

Week of 3/27-31: Transcription activation/coactivators / Rowland Akoma
Dynlacht, B.D., Hoey, T., and Tjian, R. Isolation of coactivators associated with TATA-binding protein that mediate transcriptional activation. (1991) Cell 66:563-576.

Week of 4/3-7: Genomics/yeast transcription / Kevin Spence
Holstege, F.C.P., Jennings, E.G., Wyrick, J.J., Lee, T.I., Hengartner, C.J., Green, M.R., Golub, T.R., Lander, E.S., and Young, R.A. Dissecting the Regulatory Circuitry of a Eukaryotic Genome (1998) Cell 95:717-728.

Week of 4/10-14: Transcription factors in development and disease / Shelu Patel
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A.L., and Karsenty, G. Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation. (1997) Cell 89:747-754.

Week of 4/17-21: Transcription factors in Drosophila development / Scott Hancock
Attardi, L.D., Von Seggern, D., and Tjian, R. Ectopic expression of wild-type or a dominant-negative mutant of transcription factor NTF-1 disrupts normal Drosophila development. (1993) Proc. Natl. Acad. Sci. USA 90:10563-10567.

Week of 4/24-28: Transcription factors and cancer / Takashi Kubota
Lu, H. and Levine, A.J. Human TAFII31 protein is a transcriptional coactivator of the p53 protein. (1995) Proc. Natl. Acad. Sci. USA 92:5154-5148.