Reading List

BICH 407   Classic Papers (1950s to 1980s)

Spring 2005

 

 

Week 2: Jan. 24-Jan. 28 (alpha helix)

Pauling, L., Corey, R.B., and Branson, H.R. (1951) The structure of proteins: two hydrogen-bonded helical configurations of the polypeptide chain. Proc. Natl. Acad. Sci. USA 37:205-211.

Go to http://www.pnas.org/misc/classics1.shtml for commentary.  Click on ³Article² in reference 8 to access the original article.

 

Week 3: Jan. 31-Feb. 4 (structure of DNA)

Watson, J.D. and Crick, F.H.C. (1953) Molecular structure of nucleic acids. A structure for deoxyribose nucleic acid. Nature 171:737-738.

Wilkins, M.H.F., Stokes, A.R., and Wilson, H.R. (1953) Molecular structure of nucleic acids. Molecular structure of deoxypentose nucleic acids. Nature 171:738-740.

Franklin, R.E. and Gosling, R.G. (1953) Molecular structure of nucleic acids. Molecular configuration in sodium thymonucleate. Nature 171:740-741.

Watson, J.D. and Crick, F.H.C. (1953) Genetical implications of the structure of deoxyribonucleic acid. Nature 171:964-967.

 

Week 4: Feb. 7-Feb. 11 (protein tertiary structure by X-ray diffraction of crystals)

Kendrew, J.C., Bodo, G., Dintzis, H.M., Parrish, R.G., Wyckoff, H., and Phillips, D.C. (1958) A three-dimensional model of the myoglobin molecule obtained by x-ray analysis. Nature 181:662-666.

 

Week 5: Feb. 14-Feb. 18 (DNA polymerase)

Lehman, I.R., Bessman, M.J., Simms, E.S., and Kornberg, A. (1958) Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli. J. Biol. Chem. 233:163-170.

Go to http://www.jbc.org/content/vol233/issue1/index.shtml and click on PDF to access original article.

 

Week 6: Feb. 21-Feb. 25 (semi-conservative nature of DNA replication)

Meselson, M. and Stahl, F.W. (1958) The replication of DNA in Escherichia coli. Proc. Natl. Acad. Sci. USA 44:671-682.

Go to http://www.pnas.org/cgi/content/full/101/52/17895 and http://www.pnas.org/cgi/content/full/101/52/17889 for commentaries.  Go to http://www.pnas.org/content/vol44/issue7/ and access original article through JSTOR.

 

Week 7: Feb. 28-March 4 (protein phosphorylation)

Fischer, E.H., Graves, D.J., Snyder Crittenden, E.R., and Krebs, E.G. (1959) Structure of the Site Phosphorylated in the Phosphorylase b to a Reaction.  J. Biol. Chem. 234:1698-1704.

Go to http://www.jbc.org/content/vol234/issue7/index.shtml and click on PDF to access original article.

 

Week 8: March 7-March 11 (mRNA/genetic code)

Brenner, S., Jacob, F., and Meselson, M. (1961) An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature 190:576-581.

 

Leder, P. and Nirenberg, M. (1964) RNA codewords and protein synthesis, II. Nucleotide sequence of a valine RNA codeword. Proc. Natl Acad. Sci. USA 52:420-427.

Go to http://www.pnas.org/content/vol52/issue2/ and access original article through JSTOR.

 

Week 9: Spring Break

 

Week 10: March 21-March 25 (reverse transcriptase)

Baltimore, D. (1970) RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses. Nature 226:1209-1211.

Temin, H.M. and Mizutani, S. (1970) RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus. Nature 226:1211-1213.

 

Week 11: March 28-April 1 (restriction enzymes)

Danna, K. and Nathans, D. (1971) Specific cleavage of Simian Virus 40 DNA by restriction endonuclease of Hemophilus Influenzae.  Proc. Natl. Acad. Sci. USA 68:2913-2917.

Go to http://www.pnas.org/misc/classics3.shtml for commentary.  Click on ³Article² in reference 1 to access original article.

 

Week 12: April 4-April 8 (recombinant plasmids)

Cohen, S., Chang, A., Boyer, H., and Helling, R. (1973) Construction of biologically functional bacterial plasmids in vitro. Proc. Natl. Acad. Sci. USA 70:3240-3244.

Go to http://www.pnas.org/content/vol70/issue11/ and access original article through JSTOR.

 

Week 13: April 11-April 15 (mRNA introns)

Berget, S.M., Moore, C., and Sharp, P.A. (1977) Spliced segments at the 5¹ terminus of adenovirus 2 late mRNA. Proc. Natl. Acad. Sci. USA 74:3171-3175.

Go to http://www.pnas.org/content/vol74/issue8/ and access original article through JSTOR.

 

Week 14: April 18-April 22 (self-splicing RNA)

Kruger, K., Grabowski, P.J., Zaug, A.J., Sands, J., Gottschling, D.E., and Cech, T.R. (1982) Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell 31:147-157.

 

Week 15: April 25-April 29 (PCR using Taq polymerase)

Saiki, R.K., Gelfand, D.H., Stoffel, S., Scharf, S.J., Higuchi, R., Horn, G.T., Mullis, K.B., and Erlich, H.A. (1988) Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487-491.

Access original article through http://www.jstor.org