Examples

The following images depict molecular sculptures of two objects, a dimer of amino acids (Cys-Cys) and the active site of the enzyme, mouse MMP-13. Both structures were determined in this laboratory.
The Cys-Cys dimer is the only dimer linkage among amino acids in a protein, its strength coming from the S-S covalent bond.
MMP-13 was first found in human breast cancer tissue; the object of the research is to explore the nature of inhibitor binding as a guide for the creation of potent and effective anti-cancer drugs.
These sculptures are carved from wood (oak, maple) by a CNC milling machine and are approximately 17cm (7 inches) high (or long). The images represent various steps in the learning process to produce precisely scaled 3-D molecular models.
 
 

42Cys-58Cys disulfide linkage
67

42Cys-58Cys disulfide linkage
az-10

42Cys-58Cys disulfide linkage
aw-13

42Cys-58Cys disulfide linkage
66

42Cys-58Cys disulfide linkage
b3-32

N3-Zn complex/MMP-13
b4-26

3His-Zn complex/MMP-13
b4-17

42Cys-58Cys disulfide linkage
b4-34

42Cys-58Cys disulfide linkage
aw-17

42Cys-58Cys disulfide linkage
ax-9

42Cys-58Cys disulfide linkage
ax-9-zoom

42Cys-58Cys disulfide linkage
b4-30

 

E. Meyer
Biographics Laboratory
Texas A&M University
E-Meyer@tamu.edu
Copyright  January, 2000